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Franczyk B.♦, Gluba-Brzózka A.♦, Olszewski R., Parolczyk M.♦, Rysz-Górzyńska M.♦, Rysz J.♦, miRNA biomarkers in renal disease,
International Urology and Nephrology, ISSN: 0301-1623, DOI: 10.1007/s11255-021-02922-7, Vol.54, pp.575-588, 2022 Streszczenie:
Chronic kidney disease (CKD), which is characterized by the gradual loss of kidney function, is a growing worldwide problem due to CKD-related morbidity and mortality. There are no reliable and early biomarkers enabling the monitoring, the stratification of CKD progression and the estimation of the risk of CKD-related complications, and therefore, the search for such molecules is still going on. Numerous studies have provided evidence that miRNAs are potentially important par- ticles in the CKD field. Studies indicate that some miRNA levels can be increased in patients with CKD stages III–V and hemodialysis and decreased in renal transplant recipients (miR-143, miR-145 and miR-223) as well as elevated in patients with CKD stages III–V, decreased in hemodialysis patients and even more markedly decreased in renal transplant recipients (miR-126 and miR-155). miRNA have great potential of being sensitive and specific biomarkers in kidney diseases as they are tissue specific and stable in various biological materials. Some promising non-invasive miRNA biomarkers have already been recognized in renal disease with the potential to enhance diagnostic accuracy, predict prognosis and monitor the course of disease. However, large-scale clinical trials enrolling heterogeneous patients are required to evaluate the clinical value of miRNAs. Słowa kluczowe:
Chronic kidney disease Afiliacje autorów:
| Franczyk B. | - | Medical University of Lodz (PL) | | Gluba-Brzózka A. | - | WAM Teaching Hospital (PL) | | Olszewski R. | - | IPPT PAN | | Parolczyk M. | - | inna afiliacja | | Rysz-Górzyńska M. | - | inna afiliacja | | Rysz J. | - | Medical University of Lodz (PL) |
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