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Liu X.♦, Jin S.♦, Ming M.♦, Fan C.♦, Liu H.♦, Politis D.J.♦, Kopeć M., A high throughput in-situ measurement of heat transfer in successive non-isothermal forming of sheet alloys,
Journal of Manufacturing Processes, ISSN: 1526-6125, DOI: 10.1016/j.jmapro.2024.08.048, Vol.129, pp.77-91, 2024Streszczenie: The measurement and control of the heat transfer of sheet alloys in successive non-isothermal forming cycles is crucial to achieve the desired post-form properties and microstructure, which could not as of yet be realized by using traditional test facilities. In the present research, a novel heat transfer measurement facility was designed to generate and subsequently measure the in-situ heat transfer from a sheet alloy to multi-mediums such as forming tools, air, lubricant and coating. More importantly, the facility was able to use a single sheet alloy sample to perform successive non-isothermal forming cycles, and subsequently obtain high throughput experimental results including the temperature evolution, cooling rate, mechanical properties and microstructures of the alloy. The high throughput in-situ heat transfer measurement facility identified that the cooling rate of AA7075 was 152 °C/s and the mechanical strength was over 530 MPa in the 1st forming cycle. However, it decreased to less than the critical value of 100 °C/s in the successive 10th forming cycle, leading to a low mechanical strength of only 487 MPa. The identified variations that occur in the successive non-isothermal forming cycles would improve the consistency and accuracy of part performance in large-scale manufacturing. Słowa kluczowe: High throughput in-situ measurement,Heat transfer,Successive non-isothermal forming,Sheet alloys,Microstructure Afiliacje autorów:
Liu X. | - | Imperial College London (GB) | Jin S. | - | inna afiliacja | Ming M. | - | inna afiliacja | Fan C. | - | inna afiliacja | Liu H. | - | Imperial College London (GB) | Politis D.J. | - | Imperial College London (GB) | Kopeć M. | - | IPPT PAN |
| | 140p. |
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Liu Z.♦, Moreira R.A., Dujmović A.♦, Liu H.♦, Yang B.♦, Poma A.B., Nash M.A.♦, Mapping mechanostable pulling geometries of a therapeutic anticalin/CTLA-4 protein complex,
Nano Letters, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.1c03584, Vol.22, pp.179-187, 2022Streszczenie: We used single-molecule AFM force spectroscopy (AFM-SMFS) in combination with click chemistry to mechanically dissociate anticalin, a non-antibody protein binding scaffold, from its target (CTLA-4), by pulling from eight different anchor residues. We found that pulling on the anticalin from residue 60 or 87 resulted in significantly higher rupture forces and a decrease in koff by 2–3 orders of magnitude over a force range of 50–200 pN. Five of the six internal anchor points gave rise to complexes significantly more stable than N- or C-terminal anchor points, rupturing at up to 250 pN at loading rates of 0.1–10 nN s^–1. Anisotropic network modeling and molecular dynamics simulations helped to explain the geometric dependency of mechanostability. These results demonstrate that optimization of attachment residue position on therapeutic binding scaffolds can provide large improvements in binding strength, allowing for mechanical affinity maturation under shear stress without mutation of binding interface residues. Słowa kluczowe: atomic force microscopy, protein engineering, single-molecule force spectroscopy, mechanical anisotropy, click chemistry, Go̅-Martini model, PCA Afiliacje autorów:
Liu Z. | - | inna afiliacja | Moreira R.A. | - | IPPT PAN | Dujmović A. | - | inna afiliacja | Liu H. | - | Imperial College London (GB) | Yang B. | - | inna afiliacja | Poma A.B. | - | IPPT PAN | Nash M.A. | - | inna afiliacja |
| | 200p. |
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Liu X.♦, Di B.♦, Yu X.♦, Liu H.♦, Dhawan S.♦, Politis D.J.♦, Kopeć M., Wang L.♦, Development of a Formability Prediction Model for Aluminium Sandwich Panels with Polymer Core,
Materials, ISSN: 1996-1944, DOI: 10.3390/ma15124140, Vol.15, No.12, pp.4140-1-12, 2022Streszczenie: In the present work, the compatibility relationship on the failure criteria between aluminium and polymer was established, and a mechanics-based model for a three-layered sandwich panel was developed based on the M-K model to predict its Forming Limit Diagram (FLD). A case study for a sandwich panel consisting of face layers from AA5754 aluminium alloy and a core layer from polyvinylidene difluoride (PVDF) was subsequently conducted, suggesting that the loading path of aluminium was linear and independent of the punch radius, while the risk for failure of PVDF increased with a decreasing radius and an increasing strain ratio. Therefore, the developed formability model would be conducive to the safety evaluation on the plastic forming and critical failure of composite sandwich panels. Słowa kluczowe: formability, M-K model, failure criteria, composite sandwich panel Afiliacje autorów:
Liu X. | - | Imperial College London (GB) | Di B. | - | Imperial College London (GB) | Yu X. | - | Imperial College London (GB) | Liu H. | - | Imperial College London (GB) | Dhawan S. | - | Imperial College London (GB) | Politis D.J. | - | Imperial College London (GB) | Kopeć M. | - | IPPT PAN | Wang L. | - | Imperial College London (GB) |
| | 140p. |