Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Partnerzy

Andrew J. McBain


Ostatnie publikacje
1.  Green R., Wang H., Botchey C., Zhang S. N. N., Wadsworth C., Tyrrell F., Letton J., McBain A. J., Paszek P., Krašovec R., Knight C. G., Collective peroxide detoxification determines microbial mutation rate plasticity in E. coli, PLOS Biology, ISSN: 1544-9173, DOI: 10.1371/journal.pbio.3002711, Vol.22, No.7, pp.e3002711-1-36, 2024

Streszczenie:
Mutagenesis is responsive to many environmental factors. Evolution therefore depends on the environment not only for selection but also in determining the variation available in a population. One such environmental dependency is the inverse relationship between mutation rates and population density in many microbial species. Here, we determine the mechanism responsible for this mutation rate plasticity. Using dynamical computational modelling and in culture mutation rate estimation, we show that the negative relationship between mutation rate and population density arises from the collective ability of microbial populations to control concentrations of hydrogen peroxide. We demonstrate a loss of this density-associated mutation rate plasticity (DAMP) when Escherichia coli populations are deficient in the degradation of hydrogen peroxide. We further show that the reduction in mutation rate in denser populations is restored in peroxide degradation-deficient cells by the presence of wild-type cells in a mixed population. Together, these model-guided experiments provide a mechanistic explanation for DAMP, applicable across all domains of life, and frames mutation rate as a dynamic trait shaped by microbial community composition.

Afiliacje autorów:
Green R. - inna afiliacja
Wang H. - inna afiliacja
Botchey C. - inna afiliacja
Zhang S. N. N. - inna afiliacja
Wadsworth C. - inna afiliacja
Tyrrell F. - inna afiliacja
Letton J. - inna afiliacja
McBain A. J. - inna afiliacja
Paszek P. - IPPT PAN
Krašovec R. - inna afiliacja
Knight C. G. - inna afiliacja
200p.

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