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Refilwe M.♦, Nwaji Njemuwa N., Muthumuni M.♦, Zhi-Long C.♦, Tebello N.♦, Photodynamic therapy characteristics of phthalocyanines in the presence of boron doped detonation nanodiamonds: Effect of symmetry and charge,
Phothodygnosis, ISSN: 1873-1597, DOI: 10.1016/j.pdpdt.2021.102705, Vol.37, pp.1-9, 2022 Abstract:
The synthesis, photophysicochemical and photodynamic therapy (PDT) activities of benzothiazole substituted zinc phthalocyanine (Pc): 1 (asymmetrically substituted and composed of no charges), 2 (asymmetrically substituted and composed of three positive charges), and 3 (symmetrically substituted and composed of four positive charges), are presented. The triplet and singlet oxygen quantum yields were highest for complex 2 showing the importance of asymmetry and charge. The complexes are covalently and non-covalently linked to B doped detonation nanodiamonds (B@DNDs) to yield nanohybrids (B@DNDs-1, B@DNDs-2, B@DNDs-3). The presence of B@DNDs, asymmetry and positive charge resulted in improved PDT with the lowest cell viability being observed for B@DNDs-2 at 5%. The cell viability ranged from 5% to 7% for the nanohybrids compared to 19–26% for Pcs alone. Affiliations:
| Refilwe M. | - | other affiliation | | Nwaji Njemuwa N. | - | IPPT PAN | | Muthumuni M. | - | other affiliation | | Zhi-Long C. | - | other affiliation | | Tebello N. | - | other affiliation |
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