Institute of Fundamental Technological Research
Polish Academy of Sciences

Scientific Activities




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Selected Achievements in Numbers

(in the last 3 years)

1205 680 37 13 7
PUBLICATIONS IN TOTAL PUBLICATIONS IN TOP JOURNALS PATENTS,
PROTECTION RIGHTS		 PHD THESES
AT IPPT PAN		 HABILITATIONS
AT IPPT PAN
1205 680
PUBLICATIONS IN TOTAL PUBLICATIONS IN TOP JOURNALS
37
PATENTS,
PROTECTION RIGHTS
13 7
PHD THESES
AT IPPT PAN		 HABILITATIONS
AT IPPT PAN




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Highly qualified personnel, extensive experience in research and intensive international cooperation are IPPT PAN’s key to success. Our outstanding scientists can pride themselves on numerous publications in renown scientific journals, a significant number of granted patents and many awards and distinctions.

The Institute makes every effort to provide its employees with the best scientific development, both on the national, and international level. We also know the importance of science in industry, that is why we prioritize to implement science directly and assess its results in a longer perspective. We believe that best results can only be obtained through constant scientific discourse and verification. That is why our scientists share opinions and argument with researchers from all over the world, keeping an open mind to new ideas. Such methods lead to maintaining the highest levels of our research, and combining it with the education of doctoral students that we also provide, determines the high position of our Institute.

achievements 1

achievements 2

Selected Scientific Achievements

(in the reporting year of 2023)

 Selected achievements in projects/research studies conducted in the reporting year of 2023

1.

  • We achieved impressive results in micromechanics of materials – crystal plasticity, elastic properties of nanocrystals, residual stresses in composites, and martensitic transformations in the two-dimensional problem of nanoindentation.
  • We developed methods of investigation for nano-scale fracture and we provided selected results for various fracture pairs.
  • We developed a new numerical algorithm for the creation of deformation bands in crystals, with the first ever described nonpotential growth model for significant plastic deformations.
  • We successfully used computer microtomography to build numerical models for residual stresses and heat transfer in FGM materials based on AISi Aluminum alloys.
  • We have built a nonlocal model for free transverse vibration of micro- and nanocantilever mass sensors with an arbitrary number of attached particles.
  • Unprecedented in world literature, we obtained correct numerical modeling for the transformation patterns of NiTi tubes under proportional axial-torsion loading, experimentally observed.

2.

  • We developed a mathematical model for non-identifiable immune response documenting the interactions between 5 regulatory pathways: (1) foreign RNA-activated signaling cascade, (2) NF-kappaB (3) IRF3, (4) STAT1/2, (5) interferon signaling pathway.
  • The model was designed based on a large series of experimental tests carried out on advanced apparatus at the Department of Biosystems and Soft Matter, IPPT PAN. The developed immunological response models, experimentally verified, can be applied in developing antiviral therapies.

 

Most important scientific achievements of the Institute in the reporting year of 2023 of general socio- and economic importance

1.

  • We carried out the implementation procedure for the application of Cr/Re/Al2O3 sintered composite produced in the PZML laboratory for valve seats in the internal combustion engine with an installed LPG. The mounted on the FIAT Panda engine head of the composite Cr/Re/Al2O3 will be tested under standard exploitation in traffic.
  • We designed a methodology for producing surface-modified carbon nanostructures for the application as a filler in cement matrices for the enhancement of structure materials – the obtained research results formed the basis of two patent applications.
  • We designed an ultrasound head of enhanced effectiveness in detecting failure in railway rails. We applied for a patent: “A double ultrasound head of longitudinal waves for detecting head checking/squat or combinations defects in railway rails and the method of detecting defects in railway rails using this head”, application no: 445721.

2.

  • We designed a methodology for the application of CT scans to generate 3-dimensional imaging of patient’s teeth and simulate the root canal view, i.e. we implemented teeth holograms with a visible precise anatomy of teeth canals dedicated to be presented in varied-reality Microsoft HoloLens 2 binoculars (goggles). It turned out that the proposed solutions which were based on mixed-reality could be successfully used as a method complementing the traditional approach. Additionally, it allows for the reduction of time of root canal treatment by up to 72,25%, depending on the complexity of the case, and increases its effectiveness. We also designed and implemented a solution based on augmented reality as a tool enabling a three-dimensional observation of the operation theatre from any given perspective, without any simultaneous interference in the treatment. Furthermore, we designed a methodology for using mixed reality, AI, and other technologies in distance education. A detailed description of practical achievements of general social importance was presented in a series of publications on the use of augmented reality and AI in the fields of medicine and medical education.
  • We designed an original mentoring program aimed at presenting scientific achievements to the high school youth and helping them with their choice of study. The program also supports talented youth in acquiring knowledge directly from the scientists and aims at preparing them to apply for national and international scientific courses, as well as engaging them in scientific research to show the know-how of the scientist’s profession, present the potential of the Polish science, present tangible research results, and finally to encourage young people to take up STEM education, as a way of investment in future generations.

 

Selected, most important applications of research and research and development results from the reporting year of 2023 of public importance (e.g. in public health care, environment protection and natural heritage, monument protection and cultural heritage, etc.) and economic importance (e.g. new technologies, implementations, licenses) and activities fostering innovation, should it occur.

1.

  • We demonstrated that the proper selection of sonification and scanning parameters in the process of hyperthermia, as well as the presence of magnetic nanoparticles, leads to significant shortening of ablation procedures of solid tumors and reducing the HIFU beam power necessary to induce the ablation, thus increasing the therapy safety. The obtained results will be used in preclinical trials on small animals (ablation/hyperthermia).
  • We designed a classification method for biomedical imaging based on simple text descriptions relevant to the selected characteristics of the given tissue pathology. The method used Chat GPT and VLM (vision-language models) to classify biomedical imaging based on simple descriptions related to the given tissue pathology.
  • We produced functional nanomaterials for biomedical applications, especially for cancer diseases – aiming at diagnostics and drug release, and also as protective materials against UV radiation in the form of skin preparation as an alternative to market SPF preparations.

2.

  • We designed an innovative drug delivery system that, by reacting to external stimuli such as pH or temperature, enables an independent delivery of two different drugs to the selected places in the human body. The designed systems are based on Janus nanofibers, formed by electrospinning. Their characteristic feature is such placement of the two nanofiber constituents that they have physical contact with the external environment. This enables rapid response to external stimuli, inducing independent release of medicinal substances. It is one of the crucial features that differentiates these systems from those formed coaxially, in which only the external layer has contact with the environment. One of the elements of the research was the careful selection of Janus nanofibers forming conditions with a subtle structure analysis allowing for revealing the specificity of the arrangement of both nanofiber constituent materials. Apart from the structural examinations, another crucial part of our work was researching the drug release process, as a response to both - temperature and pH variations. In the case of release induced by temperature change, the key parameter was the glass transition temperature of the used polymers. In the case when the polymer carrier is in the glassy state (T < Tg), it is practically impossible for the capsuled drug to be released due to the limited mobility of polymer chains. The release happens when reaching the increased molecular mobility after exceeding the glass transition temperature. The right selection of both polymer-carriers helps to achieve the intended release at various temperatures of both medicinal substances. In the case of drug release due to pH changes, it is crucial to select polymers that demonstrate solubility dependent on pH. In our 2023 research, we used indomethacin (IMC) and octenidine dihydrochloride (OCT) as antibacterial substances, and Eudragit E100 (EE) and polymethyl methacrylate (PMMA) as polymer carriers sensitive to pH and temperature. The obtained results demonstrated that the proposed material systems meet the expectations as carriers of the used antibacterial drugs and showed the appropriate kinetics of release in response to changes in pH and temperature. The antibacterial properties of Janus nanofibers against E. coli and S. aureus, tested in suspension tests, were pH-dependent as a result of the selective release of active substances. The biocompatibility of the Janus nanofibers was confirmed in selected tests. The tests were conducted as part of the project “Development of multi-stimuli responsive novel bi-compartmental nanofibrous membrane for dual drug synergistic co-delivery”, financed by the NAWA NCBiR program. In 2023, the research resulted in two publications and one patent application.

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