1. |
Piotrzkowska H., Litniewski J., Szymańska E.♦, Nowicki A., Quantitative sonography of basal cell carcinoma,
ULTRASOUND IN MEDICINE AND BIOLOGY, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2014.11.016, Vol.41, No.3, pp.748-759, 2015Abstract: A 30-MHz ultrasonic scanner was used to collect B-scan images together with appropriate radiofrequency echoes from diseased and healthy skin regions of patients with diagnosed basal cell carcinoma and pre-cancerous lesions (actinic keratosis). Radiofrequency data were processed to obtain the attenuation coefficient and statistics of the backscattered echo signal determination (K-distribution and effective density of scatterers [EDS]). The attenuation coefficient was significantly higher for patients with basal cell carcinoma than for healthy patients. Also, the pre-cancerous skin lesions had increased attenuation. The averaged EDS values for cancer lesions were significantly lower than those for pre-cancerous lesions and healthy skin. The successful differentiation between the tissue groups examined suggests the potential value of the attenuation coefficient and EDS for carcinoma characterization. Keywords: Quantitative ultrasound, High frequency, Human skin, Skin lesions, K-distribution, Attenuation coefficient, Tissue characterization Affiliations:
Piotrzkowska H. | - | IPPT PAN | Litniewski J. | - | IPPT PAN | Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Nowicki A. | - | IPPT PAN |
| |
2. |
Maj M.♦, Warszawik-Hendzel O.♦, Szymańska E.♦, Walecka I.♦, Rakowska A.♦, Antczak-Marczak M.♦, Kuna P.♦, Kruszewski J.♦, Nasierowska-Guttmejer A.♦, Litniewski J., Nowicki A., Olszewska M.♦, Rudnicka L.♦, High frequency ultrasonography: a complementary diagnostic method in evaluation of primary cutaneous melanoma,
GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, ISSN: 0392-0488, Vol.150, No.5, pp.595-601, 2015Abstract: Aim.
The aim of our study was to assess the usefulness of high frequency ultrasonography in the diagnosis of melanoma. Methods. We examined 84 patients with suspicious melanocytic skin lesions, including 19 cases of melanoma. In vivo high-resolution ultrasonography (30 MHz) was performed prior to excision.
Results.
In ultrasound scans early melanomas presented as flat oval or fusiform shaped structures and were clearly demarcated, while advanced melanomas were characterized by a roundish shape with less distinct borders. The ultrasonographic thickness of in situ melanomas ranged from 0.02 to 0.85 mm. In the case of invasive tumors, the mean thickness evaluated by high frequency ultrasonography was 10.7% higher compared to the Breslow Score (1.44±0.8 mm and 1.3±0.88 mm, respectively). In all melanomas of Breslow Score of 1 mm or more ultrasound also indicated a Breslow Score of 1 mm or more.
Conclusion.
High frequency ultrasound examination has limited value in differential diagnosis of melanoma, but it gives a clear picture of the size and depth of the tumor. The method should be used as a complementary method (after dermoscopy and, where applicable, reflectance confocal microscopy) in preoperative evaluation of the tumor. In some cases of locally advanced melanoma, ultrasound examination may allow to reduce the number of surgical procedures and favor the decision of a one-time surgical treatment (removal of primary tumor and sentinel lymph node biopsy at the same time). Keywords: Dermoscopy - Diagnosis - Melanoma - Microscopy, confocal - Ultrasonography Affiliations:
Maj M. | - | Medical University of Warsaw (PL) | Warszawik-Hendzel O. | - | other affiliation | Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Walecka I. | - | other affiliation | Rakowska A. | - | other affiliation | Antczak-Marczak M. | - | Medical University of Lodz (PL) | Kuna P. | - | Medical University of Lodz (PL) | Kruszewski J. | - | other affiliation | Nasierowska-Guttmejer A. | - | Central Clinical Hospital MSW (PL) | Litniewski J. | - | IPPT PAN | Nowicki A. | - | IPPT PAN | Olszewska M. | - | other affiliation | Rudnicka L. | - | Medical University of Warsaw (PL) |
| |
3. |
Piotrzkowska H., Litniewski J., Szymańska E.♦, Nowicki A., Ultrasonic Echosignal Applied to Human Skin Lesions Characterization,
ARCHIVES OF ACOUSTICS, ISSN: 0137-5075, Vol.37, No.1, pp.103-108, 2012Abstract: The paper presents a classification of the healthy skin and the skin lesions (basal cell carcinoma) basing on a statistics of the envelope of ultrasonic echoes. The echoes envelopes distributions were modeled using Rayleigh and K-distribution. The distributions were compared with empirical data to find which of them better models the statistics of the echo-signal obtained from the human skin. The results indicated that the K-distribution provides a better fit. Also, a characteristic parameter of the K-distribution, the effective number of scatterers (M), was investigated. The values of the M parameter, obtained for the skin cancer (basal cell carcinoma), were lower as compared to those obtained for the healthy skin. The results indicate that the statistical quantitative ultrasound parameters have a potential for extracting information useful for characterization of the skin condition. Keywords: statistics, K-distribution, Rayleigh distribution, ultrasonic scattering, human dermis Affiliations:
Piotrzkowska H. | - | IPPT PAN | Litniewski J. | - | IPPT PAN | Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Nowicki A. | - | IPPT PAN |
| |
4. |
Piotrzkowska H., Litniewski J., Szymańska E.♦, Nowicki A., Statistical Analysis of Ultrasound Echo for Skin Lesions Classification,
HYDROACOUSTICS, ISSN: 1642-1817, Vol.15, pp.171-178, 2012Abstract: Propagation of ultrasonic waves in the tissue is sensitive to the alternation of tissue composition and structure.. This paper presents the classification of healthy skin and skin lesions (basal cell carcinoma (BCC)) based on statistic parameters of the envelope of echosignal. The statistics of envelope of the ultrasonic signal was modeled using Rayleigh and non-Rayleigh (the K-distribution) statistics. Furthermore the characteristic parameter of K-distribution, the effective number of scaterrers (M) was investigated.
Comparison of the results obtained for region of the skin where the BCC was diagnosed and the regions of healthy skin has shown differences in the values of M parameter. These results indicate that this parameter has the potential for extracting information useful for characterizing skin lesions. Keywords: high frequency, ultrasound, basall cell carcinoma, ststistics Affiliations:
Piotrzkowska H. | - | IPPT PAN | Litniewski J. | - | IPPT PAN | Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Nowicki A. | - | IPPT PAN |
| |
5. |
Szymańska E.♦, Maj M.♦, Majsterek M.♦, Litniewski J., Nowicki A., Rudnicka L.♦, Zastosowanie ultrasonografii wysokiej częstotliwości w diagnostyce dermatologicznej – obraz ultrasonograficzny wybranych zmian skórnych,
POLSKI MERKURIUSZ LEKARSKI, ISSN: 1426-9686, Vol.31, No.181, pp.37-40, 2011Abstract: Typical diagnostic process in dermatology includes clinical assessment, dermoscopic and histopathologic examination. Microsonography was initiated in seventies and much progress in the development of high-frequency scanners occurred since that time. The aim of the study was the assessment of high frequency ultrasonography in dermatologic diagnostics. Material and methods. Examination was performed with 30 MHz ultrasound transducer with 0,1 mm resolution and 7 mm penetration. We examined patients with benign and malignant neoplasms, cicatrical alopecia and morphea. Results. Sonographically, the normal skin is composed of three layers: an epidermal entry echo, dermis and subcutaneous tissue. In healthy skin we can image small hypoechoic areas which correspond to hair folicules, vessels and sebaceous glands. Most of small skin neoplasmatic lesions were hypoechogenic and homogeneous on examination. Extensive lesions were multicomponent with normo-, hypo- and anechogenic structures. The assessment of lesion’s boarders allows sometimes to conclude the invasiveness of the lesion. Areas of skin with clinically visible atrophy showed diffuse increasing of echogenicity. In early lesions, without accomplished fibrosis, diffuse decreasing of echogenicity can be observed, that is probably caused by inflammatory infiltration. In comparison to the healthy skin, the ultrasound scan of sclerotic skin shows a wide entry echo and highly reflective, thicker dermis as a result of the collagen fibers accumulation. Conclusions. Above data suggest that ultrasonographic examination may be a valuable dermatologic diagnostic tool that completes classical dermatologic diagnostics and helps to plan the treatment. Keywords: high frequency ultrasonography, benign neoplasms, malignant neoplasms, cicatrical alopecia, morphea Affiliations:
Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Maj M. | - | Medical University of Warsaw (PL) | Majsterek M. | - | other affiliation | Litniewski J. | - | IPPT PAN | Nowicki A. | - | IPPT PAN | Rudnicka L. | - | Medical University of Warsaw (PL) |
| |
6. |
Piotrzkowska H., Litniewski J., Szymańska E.♦, Lewandowski M., Nowicki A., Statistics of envelope of high frequency ultrasound signal backscattered in human dermis,
HYDROACOUSTICS, ISSN: 1642-1817, Vol.13, pp.205-214, 2010Abstract: The scattering of ultrasonic waves depends on the size, shape, acoustical properties and concentration of scatterers in tissue. In these study K distribution of the ultrasound backscatter envelope was used to assess the structural properties of the skin tissue. The custom-designed high frequency ultrasonic scanner was applied to obtain RF B-scans of the skin in vivo at the frequency of 20-30MHz.
The results are encouraging. The K distribution models the envelope statistics very well. The parameters of the K-distribution, namely, the effective number of scatterers may be useful for the skin characterization. Keywords: skin characterization, ultrasound, K distribution Affiliations:
Piotrzkowska H. | - | IPPT PAN | Litniewski J. | - | IPPT PAN | Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Lewandowski M. | - | IPPT PAN | Nowicki A. | - | IPPT PAN |
| |
7. |
Piotrzkowska H., Litniewski J., Lewandowski M., Szymańska E.♦, Nowicki A., Use of quantitative ultrasound to measure acoustic properties of human skin,
ARCHIVES OF ACOUSTICS, ISSN: 0137-5075, Vol.34, No.4, pp.471-480, 2009Abstract: The scattering of ultrasonic waves depends on the size, shape, acoustical properties and concentration of scatterers in the tissue. The spectrum of the ultrasonic backscatter can be used to characterize non-invasively the structural and mechanical properties of tissue. We intend to apply the custom-designed high-frequency ultrasonic scanner for the skin and cutaneous lesions characterization by evaluating their attenuating and scattering properties. In this pilot study, we have explored the possibility of extracting the human skin backscattering coefficient (BC) from the ultrasonic B-scans obtained in vivo at 20–30 MHz. The measured BC values of normal skin (dermis) agree well with the published data. We have found also that the spatial resolution of the BC determination using our scanner is sufficient (aprox. 1 mm2) to characterize small skin lesions and assess their penetration depth. Keywords: attenuation coefficient, backscattering coefficient, dermis Affiliations:
Piotrzkowska H. | - | IPPT PAN | Litniewski J. | - | IPPT PAN | Lewandowski M. | - | IPPT PAN | Szymańska E. | - | Central Clinical Hospital of the MSWiA (PL) | Nowicki A. | - | IPPT PAN |
| |