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Bryliński M.♦, Prymula K.♦, Jurkowski W.♦, Kochańczyk M., Stawowczyk E.♦, Konieczny L.♦, Roterman I.♦, Prediction of Functional Sites Based on the Fuzzy Oil Drop Model,
PLOS COMPUTATIONAL BIOLOGY, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.0030094, Vol.3, No.5, pp.e94-0909-0923, 2007Abstract: A description of many biological processes requires knowledge of the 3-D structure of proteins and, in particular, the defined active site responsible for biological function. Many proteins, the genes of which have been identified as the result of human genome sequencing, and which were synthesized experimentally, await identification of their biological activity. Currently used methods do not always yield satisfactory results, and new algorithms need to be developed to recognize the localization of active sites in proteins. This paper describes a computational model that can be used to identify potential areas that are able to interact with other molecules (ligands, substrates, inhibitors, etc.). The model for active site recognition is based on the analysis of hydrophobicity distribution in protein molecules. It is shown, based on the analyses of proteins with known biological activity and of proteins of unknown function, that the region of significantly irregular hydrophobicity distribution in proteins appears to be function related. Keywords: Protein structure, Amino acid analysis, Isomerases, Protein structure prediction, Genomic databases, Structural genomics, Protein structure comparison, Oils Affiliations:
Bryliński M. | - | other affiliation | Prymula K. | - | other affiliation | Jurkowski W. | - | other affiliation | Kochańczyk M. | - | IPPT PAN | Stawowczyk E. | - | other affiliation | Konieczny L. | - | other affiliation | Roterman I. | - | Jagiellonian University (PL) |
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Bryliński M.♦, Kochańczyk M., Konieczny L.♦, Roterman I.♦, Sequence-structure-function relation characterized in silico,
In Silico Biology, ISSN: 1386-6338, Vol.6, No.6, pp.589-600, 2006Keywords: Hydrophobicity, biological function, active site, proteins of unknown biological function Affiliations:
Bryliński M. | - | other affiliation | Kochańczyk M. | - | IPPT PAN | Konieczny L. | - | other affiliation | Roterman I. | - | Jagiellonian University (PL) |
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