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Mienkina M.P.♦, Postema M.♦, Hansen C.♦, Schmitz G.♦, Modelling ultrasonic backscattering of an SPIO-MRI contrast agent,
Biomedical Engineering-Biomedizinische Technik, ISSN: 1862-278X, Vol.50, No.S1, Supplement, pp.750-751, 2005 Abstract:
The ultrasonic backscatter coefficient (BSC) of superparamagnetic iron oxide (SPIO) nanoparticles, which are used as a liver MRI contrast agent, was simulated using a Yagi backscattering model. The BSC of SPIO cores that are aggregated in the lysosomes of Kupffer cells is significantly higher (85 dB) than the BSC of non- aggregated SPIO cores. Considering in vivo concentrations, the aggregated SPIO does not elevate the BSC of the liver markedly (9x10-6 dB). Thus, the reported visibility of SPIO in clinical ultrasound cannot be explained by classical scattering theory. Other non-linear effects need to be taken into account. Affiliations:
| Mienkina M.P. | - | other affiliation | | Postema M. | - | other affiliation | | Hansen C. | - | CERN (CH) | | Schmitz G. | - | other affiliation |
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