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Bilmin K.♦, Synoradzki K.J.♦, Czarnecka A.M.♦, Spałek M.J.♦, Kujawska T., Solnik M.♦, Merks P.♦, Toro M.D.♦, Rejdak R.♦,
Fiedorowicz M.♦, New perspectives for eye-sparing treatment strategies in primary uveal melanoma,
Cancers, ISSN: 2072-6694, DOI: 10.3390/cancers14010134, Vol.14, No.1, pp.134-1-21, 2022 Abstract:
Uveal melanoma is the most common intraocular cancer. The current eye-sparing treatment options include mostly plaque brachytherapy. However, the effectiveness of these methods is still unsatisfactory. In this article, we review several possible new treatment options. These methods may be based on the physical destruction of the cancerous cells by applying ultrasounds. Another approach may be based on improving the penetration of the anti-cancer agents. It seems that the most promising technologies from this group are based on enhancing drug delivery by applying electric current. Finally, new advanced nanoparticles are developed to combine diagnostic imaging and therapy (i.e., theranostics). However, these methods are mostly at an early stage of development. More advanced studies on experimental animals and clinical trials would be needed to introduce some of these techniques to routine clinical practice. Keywords:
uveal melanoma, HIFU, iontophoresis, electrotherapy, nanoparticles, theranostics Affiliations:
| Bilmin K. | - | Mossakowski Medical Research Centre, Polish Academy of Sciences (PL) | | Synoradzki K.J. | - | Mossakowski Medical Research Centre, Polish Academy of Sciences (PL) | | Czarnecka A.M. | - | Mossakowski Medical Research Centre, Polish Academy of Sciences (PL) | | Spałek M.J. | - | Maria Sklodowska-Curie National Research Institute of Oncology (PL) | | Kujawska T. | - | IPPT PAN | | Solnik M. | - | Medical University of Warsaw (PL) | | Merks P. | - | Cardinal Stefan Wyszyński University in Warsaw (PL) | | Toro M.D. | - | University of Zurich (CH) | | Rejdak R. | - | Medical University of Lublin (PL) | |
Fiedorowicz M. | - | Mossakowski Medical Research Centre, Polish Academy of Sciences (PL) |
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