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Fallahi A.♦, Yazdi I.♦, Serex L.♦, Lasha E.♦, Faramarzi N.♦, Tarlan F.♦, Avci H.♦, Almeida R.♦, Sharifi F.♦, Rinoldi C.♦, Gomes M.E.♦, Shin S.R.♦, Khademhosseini A.♦, Akbari M.♦, Tamayol A.♦, Customizable composite fibers for engineering skeletal muscle models,
ACS BIOMATERIALS SCIENCE & ENGINEERING, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.9b00992, Vol.6, No.2, pp.1112-1123, 2020 Abstract:
Engineering tissue-like scaffolds that can mimic the microstructure, architecture, topology, and mechanical properties of native tissues while offering an excellent environment for cellular growth has remained an unmet need. To address these challenges, multi-compartment composite fibers are fabricated. These fibers can be assembled through textile processes to tailor tissue-level mechanical and electrical properties independent of cellular level components. Textile technologies also allow controlling the distribution of different cell types and microstructure of fabricated constructs and directing cellular growth within 3D microenvironment. Here, we engineered composite fibers from biocompatible cores and biologically relevant hydrogel sheaths. The fibers are mechanically robust to be assembled using textile processes and could support adhesion, proliferation and maturation of cell populations important for engineering of skeletal muscles. We also demonstrated that the changes in the electrical conductivity of the multi-compartment fibers could significantly enhance myogenesis in vitro. Keywords:
reinforced fibers, biotextiles, tissue engineering, organ weaving, interpenetrating network hydrogels, skeletal muscles Affiliations:
| Fallahi A. | - | Paul Scherrer Institut (CH) | | Yazdi I. | - | Massachusetts Institute of Technology (US) | | Serex L. | - | Brigham and Women's Hospital (US) | | Lasha E. | - | Brigham and Women's Hospital (US) | | Faramarzi N. | - | Brigham and Women's Hospital (US) | | Tarlan F. | - | Brigham and Women's Hospital (US) | | Avci H. | - | Eskisehir Osmangazi University (TR) | | Almeida R. | - | Brigham and Women's Hospital (US) | | Sharifi F. | - | Massachusetts Institute of Technology (US) | | Rinoldi C. | - | other affiliation | | Gomes M.E. | - | University of Minho (PT) | | Shin S.R. | - | Massachusetts Institute of Technology (US) | | Khademhosseini A. | - | Massachusetts Institute of Technology (US) | | Akbari M. | - | Brigham and Women's Hospital (US) | | Tamayol A. | - | Massachusetts Institute of Technology (US) |
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