| 1. |
Ankers John M.♦, Awais R.♦, Jones Nicholas A.♦, Boyd J.♦, Ryan S.♦, Adamson Antony D.♦, Harper Claire V.V.♦, Bridge L.♦, Spiller David G.♦, Jackson Dean A.♦, Paszek P.♦, Sée V.♦, White Michael R.R.♦, Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation,
eLife, ISSN: 2050-084X, DOI: 10.7554/eLife.10473, Vol.5, pp.e10473-1-35, 2016 Abstract:
Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised differently depending on the timing of an inflammatory signal. Using iterative experimental and computational analyses, we show physical and functional interactions between NF-κB and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators. These interactions modulate the NF-κB response. In S-phase, the NF-κB response was delayed or repressed, while cell cycle progression was unimpeded. By contrast, activation of NF-κB at the G1/S boundary resulted in a longer cell cycle and more synchronous initial NF-κB responses between cells. These data identify new mechanisms by which the cellular response to stress is differentially controlled at different stages of the cell cycle. Affiliations:
| Ankers John M. | - | other affiliation | | Awais R. | - | other affiliation | | Jones Nicholas A. | - | Massachusetts Institute of Technology (US) | | Boyd J. | - | other affiliation | | Ryan S. | - | other affiliation | | Adamson Antony D. | - | other affiliation | | Harper Claire V.V. | - | University of Manchester
(GB) | | Bridge L. | - | other affiliation | | Spiller David G. | - | other affiliation | | Jackson Dean A. | - | other affiliation | | Paszek P. | - | other affiliation | | Sée V. | - | other affiliation | | White Michael R.R. | - | University of Manchester
(GB) |
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| 2. |
Jones N♦, Wierzbicki T., A study of the higher modal dynamic plastic response of beams,
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES, ISSN: 0020-7403, DOI: 10.1016/0020-7403(76)90079-5, Vol.18, No.11-12, pp.533-542, 1976Abstract:
A theoretical and experimental investigation into the higher modal dynamic plastic response of fully clamped beams is reported herein. It is shown that the influence of geometry changes or finite-deflections is important which agrees with previous studies on the dynamic plastic behavior of uniformly loaded beams. It appears that the higher modal response of beams is a more efficient means of absorbing a given magnitude of kinetic energy than a single modal response. Affiliations:
| Jones N | - | Massachusetts Institute of Technology (US) | | Wierzbicki T. | - | IPPT PAN |
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