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Bobrowski A.♦, Lipniacki T., Piechór K., Rudnicki R.♦, Asymptotic behavior of distributions of mRNA and protein levels in a model of stochastic gene expression,
JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS, ISSN: 0022-247X, DOI: 10.1016/j.jmaa.2006.11.043, Vol.333, No.2, pp.753-769, 2007 Abstract:
The paper is devoted to a stochastic process introduced in the recent paper by Lipniacki et al. [T. Lipniacki, P. Paszek, A. Marciniak-Czochra, A.R. Brasier, M. Kimmel, Transcriptional stochasticity in gene expression, J. Theor. Biol. 238 (2006) 348–367] in modelling gene expression in eukaryotes. Starting from the full generator of the process we show that its distributions satisfy a (Fokker–Planck-type) system of partial differential equations. Then, we construct a c0 Markov semigroup in L1 space corresponding to this system. The main result of the paper is asymptotic stability of the involved semigroup in the set of densities. Keywords:
Piece-wise deterministic process, Stochastic gene expression, Semigroups of operators, Feller semigroups, Dual semigroups, Markov semigroups, Asymptotic stability Affiliations:
| Bobrowski A. | - | Lublin University of Technology (PL) | | Lipniacki T. | - | IPPT PAN | | Piechór K. | - | IPPT PAN | | Rudnicki R. | - | Institute of Mathematics, Polish Academy of Sciences (PL) |
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