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Refilwe M.♦, Tendamudzimu T.♦, Muthumuni M.♦, Nwaji N.♦, Kevin L.♦, Tebello N.♦, Theoretical and photodynamic therapy characteristics of heteroatom doped detonation nanodiamonds linked to asymmetrical phthalocyanine for eradication of breast cancer cells,
Journal of Luminescence, ISSN: 0022-2313, DOI: 10.1016/j.jlumin.2020.117465, Vol.227, pp.1-13, 2020 Abstract:
An amide mono substituted benzothiozole phthalocyanine: zinc(II) 3-(4-((3,17,23-tris(4-(benzo [d]thiazol-2-yl)
phenoxy)-9-yl)oxy) phenyl)amide phthalocyanine (NH2BzPc) was covalently linked to undoped and heteroatom
doped detonation nanodiamonds (DNDs): B@DNDs, P@DNDs, S@DNDs, N@DNDs, and S&N@DNDs There is a
drastic decrease in highest occupied molecular orbital (HOMO) – lowest unoccupied molecular orbital (LUMO)
energy gaps for nanoconjugates compared to DNDs alone. B@DNDs-NH2BzPc, S&N@DNDs-NH2BzPc, and
P@DNDs-NH2BzPc showed superior photodynamic therapy (PDT) effects. DNDs-NH2BzPc also had a small
HOMO-LUMO gap, but did not show improved PDT activity compared to the Pc alone, suggesting doping of
DNDs is important. This study shows improved PDT effect on Michigan Cancer Foundation-7 breast cancer lines
at 7.63%, 7.62% and 6.5% cell viability for P@DNDs-NH2BzPc, S&N@DNDs-NH2BzPc and B@DNDs-NH2BzPc,
respectively Affiliations:
| Refilwe M. | - | other affiliation | | Tendamudzimu T. | - | other affiliation | | Muthumuni M. | - | other affiliation | | Nwaji N. | - | other affiliation | | Kevin L. | - | other affiliation | | Tebello N. | - | other affiliation |
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