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Kardynska M.♦, Smieja J.♦, Paszek P., Puszyński K.♦, Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets,
International Journal of Molecular Sciences, ISSN: 1422-0067, DOI: 10.3390/ijms23126604, Vol.23, No.12, pp.6604-1-17, 2022 Abstract:
Mathematical modeling of signaling pathways and regulatory networks has been supporting experimental research for some time now. Sensitivity analysis, aimed at finding model parameters whose changes yield significantly altered cellular responses, is an important part of modeling work. However, sensitivity methods are often directly transplanted from analysis of technical systems, and thus, they may not serve the purposes of analysis of biological systems. This paper presents a novel sensitivity analysis method that is particularly suited to the task of searching for potential molecular drug targets in signaling pathways. Using two sample models of pathways, p53/Mdm2 regulatory module and IFN- Keywords:
bioinformatics, chemotherapy, sensitivity analysis, molecular drug targets, systems biology Affiliations:
| Kardynska M. | - | other affiliation | | Smieja J. | - | other affiliation | | Paszek P. | - | IPPT PAN | | Puszyński K. | - | Silesian University of Technology (PL) |
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