Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Pracownicy

mgr Magdalena Bartolewska

Zakład Biosystemów i Miękkiej Materii (ZBiMM)
Pracownia Zastosowań Nanomateriałów Polimerowych (PZNP)
doktorantka
telefon: (+48) 22 826 12 81 wewn.: 422
pokój: 227
e-mail:

Ostatnie publikacje
1.  Shah Syed A., Sohail M., Nakielski P., Rinoldi C., Zargarian Seyed S., Kosik-Kozioł A., Yasamin Z., Ali Haghighat Bayan M., Zakrzewska A., Rybak D., Bartolewska M., Pierini F., Integrating Micro- and Nanostructured Platforms and Biological Drugs to Enhance Biomaterial-Based Bone Regeneration Strategies, BIOMACROMOLECULES, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.4c01133, pp.A-W, 2024

Streszczenie:
Bone defects resulting from congenital anomalies and trauma pose significant clinical challenges for orthopedics surgeries, where bone tissue engineering (BTE) aims to address these challenges by repairing defects that fail to heal spontaneously. Despite numerous advances, BTE still faces several challenges, i.e., difficulties in detecting and tracking implanted cells, high costs, and regulatory approval hurdles. Biomaterials promise to revolutionize bone grafting procedures, heralding a new era of regenerative medicine and advancing patient outcomes worldwide. Specifically, novel bioactive biomaterials have been developed that promote cell adhesion, proliferation, and differentiation and have osteoconductive and osteoinductive characteristics, stimulating tissue regeneration and repair, particularly in complex skeletal defects caused by trauma, degeneration, and neoplasia. A wide array of biological therapeutics for bone regeneration have emerged, drawing from the diverse spectrum of gene therapy, immune cell interactions, and RNA molecules. This review will provide insights into the current state and potential of future strategies for bone regeneration.

Afiliacje autorów:
Shah Syed A. - IPPT PAN
Sohail M. - inna afiliacja
Nakielski P. - IPPT PAN
Rinoldi C. - IPPT PAN
Zargarian Seyed S. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Yasamin Z. - IPPT PAN
Ali Haghighat Bayan M. - IPPT PAN
Zakrzewska A. - IPPT PAN
Rybak D. - IPPT PAN
Bartolewska M. - IPPT PAN
Pierini F. - IPPT PAN
140p.
2.  Bartolewska M., Kosik-Kozioł A., Korwek Z., Krysiak Z., Devis M., Mazur M., Giuseppe F., Pierini F., Eumelanin-Enhanced Photothermal Disinfection of Contact Lenses Using a Sustainable Marine Nanoplatform Engineered with Electrospun Nanofibers, ADVANCED HEALTHCARE MATERIALS, ISSN: 2192-2659, DOI: 10.1002/adhm.202402431, pp.2402431-1-21, 2024

Streszczenie:
Bacterial keratitis (BK) is a severe eye infection commonly associated with Staphylococcus aureus (S. aureus), posing a significant risk to vision, especially among contact lens wearers. This research introduces a novel smart nanoplatform (deMS@cNF), developed from demineralized mussel shells (deMS) and reinforced with chitin (CT) nanofibrils, specifically designed for portable photothermal disinfection of contact lenses. The nanoplatform leverages the photothermal properties of eumelanin in mussel shells (MS), which, when activated by a simple bike flashlight, rapidly heats to temperatures up to 95 °C, effectively destroying bacterial contamination. In vitro tests demonstrate that the nanoplatform is biocompatible and non-toxic, making it suitable for medical applications. This study highlights an innovative approach to converting marine biowaste into a safe, effective, and low-cost portable method for disinfecting contact lenses, showcasing the potential of the deMS@cNF platform for broader antimicrobial applications.

Afiliacje autorów:
Bartolewska M. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Korwek Z. - IPPT PAN
Krysiak Z. - IPPT PAN
Devis M. - inna afiliacja
Mazur M. - inna afiliacja
Giuseppe F. - inna afiliacja
Pierini F. - IPPT PAN
140p.
3.  Haghighat Bayan M.A., Rinoldi C., Kosik-Kozioł A., Bartolewska M., Rybak D., Zargarian S., Shah S., Krysiak Z., Zhang S., Lanzi M., Nakielski P., Ding B., Pierini F., Solar-to-NIR Light Activable PHBV/ICG Nanofiber-Based Face Masks with On-Demand Combined Photothermal and Photodynamic Antibacterial Properties, Advanced Materials Technologies, ISSN: 2365-709X, DOI: 10.1002/admt.202400450, pp.2400450-1-18, 2024

Streszczenie:
Hierarchical nanostructures fabricate by electrospinning in combination with light-responsive agents offer promising scenarios for developing novel activable antibacterial interfaces. This study introduces an innovative antibacterial face mask developed from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers integrated with indocyanine green (ICG), targeting the urgent need for effective antimicrobial protection for community health workers. The research focuses on fabricating and characterizing this nanofibrous material, evaluating the mask's mechanical and chemical properties, investigating its particle filtration, and assessing antibacterial efficacy under photothermal conditions for reactive oxygen species (ROS) generation. The PHBV/ICG nanofibers are produced using an electrospinning process, and the nanofibrous construct's morphology, structure, and photothermal response are investigated. The antibacterial efficacy of the nanofibers is tested, and substantial bacterial inactivation under both near-infrared (NIR) and solar irradiation is demonstrated due to the photothermal response of the nanofibers. The material's photothermal response is further analyzed under cyclic irradiation to simulate real-world conditions, confirming its durability and consistency. This study highlights the synergistic impact of PHBV and ICG in enhancing antibacterial activity, presenting a biocompatible and environmentally friendly solution. These findings offer a promising path for developing innovative face masks that contribute significantly to the field of antibacterial materials and solve critical public health challenges.

Afiliacje autorów:
Haghighat Bayan M.A. - IPPT PAN
Rinoldi C. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Bartolewska M. - IPPT PAN
Rybak D. - IPPT PAN
Zargarian S. - IPPT PAN
Shah S. - IPPT PAN
Krysiak Z. - IPPT PAN
Zhang S. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Nakielski P. - IPPT PAN
Ding B. - Donghua University (CN)
Pierini F. - IPPT PAN
100p.
4.  Zargarian S., Zakrzewska A., Kosik-Kozioł A., Bartolewska M., Shah S., Li X., Su Q., Petronella F., Marinelli M., De Sio L., Lanzi M., Ding B., Pierini F., Advancing resource sustainability with green photothermal materials: Insights from organic waste-derived and bioderived sources, nanotechnology reviews, ISSN: 2191-9097, DOI: 10.1515/ntrev-2024-0100, Vol.13, No.1, pp.20240100-1-39, 2024

Streszczenie:
Recently, there has been a surge of interest in developing new types of photothermal materials driven by the ongoing demand for efficient energy conversion, environmental concerns, and the need for sustainable solutions. However, many existing photothermal materials face limitations such as high production costs or narrow absorption bands, hindering their widespread application. In response to these challenges, researchers have redirected their focus toward harnessing the untapped potential of organic waste-derived and bioderived materials. These materials, with photothermal properties derived from their intrinsic composition or transformative processes, offer a sustainable and cost-effective alternative. This review provides an extended categorization of organic waste-derived and bioderived materials based on their origin. Additionally, we investigate the mechanisms underlying the photothermal properties of these materials. Key findings highlight their high photothermal efficiency and versatility in applications such as water and energy harvesting, desalination, biomedical applications, deicing, waste treatment, and environmental remediation. Through their versatile utilization, they demonstrate immense potential in fostering sustainability and support the transition toward a greener and more resilient future. The authors’ perspective on the challenges and potentials of platforms based on these materials is also included, highlighting their immense potential for real-world implementation.

Słowa kluczowe:
photothermal materials, organic waste valorization, bioderived materials

Afiliacje autorów:
Zargarian S. - IPPT PAN
Zakrzewska A. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Bartolewska M. - IPPT PAN
Shah S. - IPPT PAN
Li X. - Donghua University (CN)
Su Q. - inna afiliacja
Petronella F. - inna afiliacja
Marinelli M. - inna afiliacja
De Sio L. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Ding B. - Donghua University (CN)
Pierini F. - IPPT PAN
70p.
5.  Zargarian S., Kupikowska-Stobba B., Kosik-Kozioł A., Bartolewska M., Zakrzewska A., Rybak D., Bochenek K., Osial M., Pierini F., Light-responsive biowaste-derived and bio-inspired textiles: Dancing between bio-friendliness and antibacterial functionality, Materials Today Chemistry, ISSN: 2468-5194, DOI: 10.1016/j.mtchem.2024.102281, Vol.41, pp.102281-1-15, 2024

Streszczenie:
Functional antibacterial textiles fabricated from a hybrid of organic waste-derived and bio-inspired materials offer sustainable solutions for preventing microbial infections. In this work, we developed a novel antibacterial textile created through the valorization of spent coffee grounds (SCG). Electrospinning and electrospraying techniques were employed to integrate the biowaste within a polymeric nanofiber matrix, ensuring uniform particle distribution and providing structural support for enhanced applicability. Modification with polydopamine (PDA) significantly enhanced the textile's photothermal performance. Specific attention was paid to understanding the relation between temperature change and key variables, including the surrounding liquid volume, textile layer stacking, and applied laser power. Developed platforms demonstrated excellent photothermal stability. While the SCG-based textile demonstrated exceptional biocompatibility, the PDA-modified textile effectively eradicated Staphylococcus aureus (S. aureus) under near-infrared (NIR) irradiation. The developed textiles in our work demonstrate a dynamic balance between biocompatibility and on-demand antibacterial functionality, offering adaptable solutions in accordance with the desired application.

Słowa kluczowe:
Organic waste valorization, Spent coffee grounds, Micro-nanostructured textiles, Bio-inspired photothermal agents, Polydopamine, Antibacterial textiles

Afiliacje autorów:
Zargarian S. - IPPT PAN
Kupikowska-Stobba B. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Bartolewska M. - IPPT PAN
Zakrzewska A. - IPPT PAN
Rybak D. - IPPT PAN
Bochenek K. - IPPT PAN
Osial M. - IPPT PAN
Pierini F. - IPPT PAN
70p.

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