| 1. |
Olusegun S.♦, Souza Guilhermina de O.♦, Sutuła S.♦, Osial M., Krajewski M.♦, Pękała M.♦, Sobczak K.♦, Felis E.♦, Krysiński P.♦, Methotrexate anti-cancer drug removal using Gd-doped Fe3O4: Adsorption mechanism, thermal desorption and reusability,
Groundwater for Sustainable Development, ISSN: 2352-801X, DOI: 10.1016/j.gsd.2024.101103, Vol.25, pp.1-9, 2024 Keywords:
Adsorption,Thermal desorption,Gd-doped Fe3O4,Methotrexate Affiliations:
| Olusegun S. | - | other affiliation | | Souza Guilhermina de O. | - | other affiliation | | Sutuła S. | - | other affiliation | | Osial M. | - | IPPT PAN | | Krajewski M. | - | other affiliation | | Pękała M. | - | other affiliation | | Sobczak K. | - | other affiliation | | Felis E. | - | other affiliation | | Krysiński P. | - | other affiliation |
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| 2. |
Olusegun S.♦, Osial M., Majkowska-Pilip A.♦, Żelechowska-Matysiak K.♦, Nieciecka D.♦, Krajewski M.♦, Pękała M.♦, Krysiński P.♦, Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application,
CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.03.102, pp.1-10, 2023Abstract:
Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells. Affiliations:
| Olusegun S. | - | other affiliation | | Osial M. | - | IPPT PAN | | Majkowska-Pilip A. | - | other affiliation | | Żelechowska-Matysiak K. | - | other affiliation | | Nieciecka D. | - | other affiliation | | Krajewski M. | - | other affiliation | | Pękała M. | - | other affiliation | | Krysiński P. | - | other affiliation |
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| 3. |
Olusegun S.♦, Osial M., Souza Taiane G.♦, Krajewski M.♦, Rodrigues G.L.S.♦, Pękała M.♦, Krysiński P.♦, Comparative characteristics and enhanced removal of tetracycline and ceftriaxone by Fe3 O 4 -lignin and Fe 3 O4 -carbon-based lignin: Mechanism, thermodynamic evaluation, and DFT calculation,
Journal of Molecular Liquids, ISSN: 0167-7322, DOI: 10.1016/j.molliq.2022.121075, Vol.371, No.121075, pp.1-16, 2023Abstract:
In this study, eco-friendly Fe3O4-lignin (FeL) and Fe3O4-carbon-based lignin (FeCL) were synthesized, characterized, and applied for the adsorption of tetracycline (TRC) and ceftriaxone (CEF). Comparative characterization showed that the BET-specific surface area of FeCL is 27 m2/g more than that of FeL. The difference in their morphologies is insignificant, and the particle sizes range between 5 and 15 nm. There is a reduction in the oxygen content and hydroxyl group of FeCL as shown from the EDS and FTIR spectra respectively, compared with FeL. The adsorption capacity for the removal of TRC at 333 K is 156 and 148 mg g−1 by FeL and FeCL, respectively; while that of CEF are virtually the same. FeL and FeCL adsorption capacity for TRC increases with temperatures (endothermic), but decreases (exothermic) for CEF. The combination of experimental and computational approaches gave insight into the mechanisms of the adsorption process. The mechanisms of TRC and CEF adsorption by FeL and FeCL are the electrostatic attraction, hydrophobic, and π-π interaction, while only FeL shows the possibility of hydrogen bond with both TRC and CEF. The study demonstrated that the synthesized material can be reused for up to 3 cycles without an alarming loss of efficiency capacity.
Graphical abstract Keywords:
Lignin,antibiotics,Adsorption mechanisms,Thermodynamics Affiliations:
| Olusegun S. | - | other affiliation | | Osial M. | - | IPPT PAN | | Souza Taiane G. | - | other affiliation | | Krajewski M. | - | other affiliation | | Rodrigues G.L.S. | - | other affiliation | | Pękała M. | - | other affiliation | | Krysiński P. | - | other affiliation |
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| 4. |
Gawęda W.♦, Osial M.♦, Żuk M.T.♦, Pękała M.♦, Bilewicz A.♦, Krysiński P.♦, Lanthanide-doped SPIONs bioconjugation with trastuzumab for potential multimodal anticancer activity and magnetic hyperthermia,
Nanomaterials, ISSN: 2079-4991, DOI: 10.3390/nano10020288, Vol.10, No.2, pp.1-14, 2020Keywords:
superparamagnetc iron oxide nanoparticles, SPIONs, trastuzumab, magnetic hyperthermia, antitumor therapy Affiliations:
| Gawęda W. | - | other affiliation | | Osial M. | - | other affiliation | | Żuk M.T. | - | NanoThea Inc. (PL) | | Pękała M. | - | other affiliation | | Bilewicz A. | - | other affiliation | | Krysiński P. | - | other affiliation |
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| 5. |
Osial M.♦, Rybicka P.♦, Pękała M.♦, Cichowicz G.♦, Cyrański Michał K.♦, Krysiński P.♦, Easy synthesis and characterization of holmium-doped SPIONs,
Nanomaterials, ISSN: 2079-4991, DOI: 10.3390/nano8060430, Vol.8, No.6, pp.1-15, 2018Keywords:
superparamagnetic iron oxide nanoparticles, SPIONs, rare-earth doping, holmium, endoradiotherapy Affiliations:
| Osial M. | - | other affiliation | | Rybicka P. | - | other affiliation | | Pękała M. | - | other affiliation | | Cichowicz G. | - | other affiliation | | Cyrański Michał K. | - | other affiliation | | Krysiński P. | - | other affiliation |
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