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Polish Academy of Sciences

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Małgorzata Lewandowska-Szumieł


Recent publications
1.  Zaszczyńska A., Gradys A.D., Ziemiecka A., Szewczyk P., Tymkiewicz R., Lewandowska-Szumieł M., Stachewicz U., Sajkiewicz P.Ł., Enhanced Electroactive Phases of Poly(vinylidene Fluoride) Fibers for Tissue Engineering Applications, International Journal of Molecular Sciences, ISSN: 1422-0067, DOI: 10.3390/ijms25094980, Vol.25, No.9, pp.4980-1-25, 2024

Abstract:
Nanofibrous materials generated through electrospinning have gained significant attention in tissue regeneration, particularly in the domain of bone reconstruction. There is high interest in designing a material resembling bone tissue, and many scientists are trying to create materials applicable to bone tissue engineering with piezoelectricity similar to bone. One of the prospective candidates is highly piezoelectric poly(vinylidene fluoride) (PVDF), which was used for fibrous scaffold formation by electrospinning. In this study, we focused on the effect of PVDF molecular weight (180,000 g/mol and 530,000 g/mol) and process parameters, such as the rotational speed of the collector, applied voltage, and solution flow rate on the properties of the final scaffold. Fourier Transform Infrared Spectroscopy allows for determining the effect of molecular weight and processing parameters on the content of the electroactive phases. It can be concluded that the higher molecular weight of the PVDF and higher collector rotational speed increase nanofibers’ diameter, electroactive phase content, and piezoelectric coefficient. Various electrospinning parameters showed changes in electroactive phase content with the maximum at the applied voltage of 22 kV and flow rate of 0.8 mL/h. Moreover, the cytocompatibility of the scaffolds was confirmed in the culture of human adipose-derived stromal cells with known potential for osteogenic differentiation. Based on the results obtained, it can be concluded that PVDF scaffolds may be taken into account as a tool in bone tissue engineering and are worth further investigation.

Keywords:
scaffolds,polymers,piezoelectricity,bone tissue engineering,nanofibers,regenerative medicine

Affiliations:
Zaszczyńska A. - IPPT PAN
Gradys A.D. - IPPT PAN
Ziemiecka A. - other affiliation
Szewczyk P. - other affiliation
Tymkiewicz R. - IPPT PAN
Lewandowska-Szumieł M. - other affiliation
Stachewicz U. - AGH University of Science and Technology (PL)
Sajkiewicz P.Ł. - IPPT PAN
2.  Mościcki T. P., Psiuk R., Jarząbek D. M., Ciemiorek-Bartkowska M., Kulikowski K., Jasiński J., Włoczewski M., Lewandowska-Szumieł M., Effect of titanium and deposition parameters on microstructure and mechanical properties of W-Ti-B thin films deposited by High Power Impulse Magnetron Sputtering, SURFACE AND COATINGS TECHNOLOGY, ISSN: 0257-8972, DOI: 10.1016/j.surfcoat.2024.130915, Vol.485, No.130915, pp.1-13, 2024

Abstract:
Tungsten diboride alloyed with transition metals provides an opportunity to obtain exceptional mechanical, physical, and chemical properties. We report a strategy for designing and synthesizing of superhard and low-compressible ceramic thin films with increased toughness and lowered residual stresses (σ < −0.9 GPa) deposited with high-power impulse magnetron sputtering (HiPIMS) from one target. The addition of 7–12 % titanium promotes additional strengthening mechanisms of the layers in one material, leading to the improvement of wear resistance compared to an alloyed WB2-z yet at even higher hardness 43.8 ± 2.1 GPa and nanoindentation toughness 4.9 ± 0.2 MPa√m. The compression of the micropillar shows that titanium addition changed the type of nanoindentation from cracking along the slip plane to bulging on the top of the pillar and next the crack initiation along column boundaries. The highest adhesion of the layers is obtained for addition of 7 % titanium and in all cases the wear has abrasive character. The controlled use of 200 μs pulses during synthesis with HiPIMS allows for an increase in the deposition rate and maintaining exceptional mechanical properties of the layers even at a substrate temperature of 300 °C.

Keywords:
Ternary transition metal diboride thin films, Mechanical properties, HiPIMS magnetron sputtering, Wear resistance and adhesion

Affiliations:
Mościcki T. P. - IPPT PAN
Psiuk R. - IPPT PAN
Jarząbek D. M. - IPPT PAN
Ciemiorek-Bartkowska M. - other affiliation
Kulikowski K. - other affiliation
Jasiński J. - other affiliation
Włoczewski M. - other affiliation
Lewandowska-Szumieł M. - other affiliation
3.  Kucharska M., Walenko K., Lewandowska-Szumieł M., Brynk T., Jaroszewicz J., Ciach T., Chitosan and composite microsphere-based scaffold for bone tissue engineering: evaluation of tricalcium phosphate content influence on physical and biological properties, JOURNAL OF MATERIALS SCIENCE, ISSN: 0022-2461, DOI: 10.1007/s10856-015-5464-9, Vol.26, No.143, pp.1-12, 2015

Abstract:
In the hereby presented work the authors describe a technique of high-compression-resistant biodegradable bone scaffold preparation. The methodology is based on the agglomeration of chitosan (CH) and chitosan/β-tricalcium phosphate (CH/TCP) microspheres and represents a novel approach to 3D matrices design for bone tissue engineering application. The materials were prepared from high deacetylation degree chitosan. The authors describe the method for scaffold fabrication, essential properties of the materials manufactured and the influence of various TCP concentrations on material morphology, mechanical properties (for dry and hydrated materials) and preliminary study on the interaction between CH or CH/TCP scaffolds and within cultured MG-63 osteoblast-like cells. The properties of the obtained materials were significantly affected by the calcium phosphate content, which had a particular influence on the granule microstructure, size distribution and inner biomaterial pore size. The water uptake ability was found to be lower for the materials enriched with the inorganic phase and tended to decrease with the increasing calcium phosphate concentration. The evaluation of mechanical properties has revealed that scaffolds produced with the usage of granule-based technology display a potential to be used as a load-bearing material since the Young’s modulus values were limited to the range of 200–500 MPa for dry materials and 15–20 MPa for the hydrated state of the scaffolds. The cell number, identified in three time points (48 h, 7 and 14 days) by Pico Green assay, was lower for the materials enriched with inorganic phase (75 % of control), however cell distribution, when compared to CH only biomaterial, was acknowledged as steadier on the surface of the material containing the highest calcium phosphate concentration.

Affiliations:
Kucharska M. - other affiliation
Walenko K. - other affiliation
Lewandowska-Szumieł M. - other affiliation
Brynk T. - Warsaw University of Technology (PL)
Jaroszewicz J. - other affiliation
Ciach T. - Warsaw University of Technology (PL)

Conference abstracts
1.  Zaszczyńska A., Gradys A., Tymkiewicz R., Lewandowska-Szumieł M., Sajkiewicz P.Ł., ENHANCED ELECTROACTIVE PHASES OF POLYVINYLIDENE FLUORIDE NANOFIBERS FOR BONE TISSUE ENGINEERING APPLICATIONS, ICSAAM 2023, The 10th International Conference on Structural Analysis of Advanced Materials, 2023-09-10/09-14, Zakyntos (GR), pp.1-3, 2023
2.  Zaszczyńska A., Cieciuch A., Gradys A., Lewandowska-Szumieł M., Sajkiewicz P., Cellular studies on stromal cells and piezoelectric nanofibers subjected to ultrasounds stimulations for medical devices, UK-Poland Bioinspired Materials Conference, 2020-11-23/11-24, Lancaster (GB), pp.127-127, 2020

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