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Miętus M.♦, Kolankowski K.♦, Gołofit T.♦, Denis P., Bandzerewicz A.♦, Spychalski M.♦, Mąkosa-Szczygieł M.♦, Pilarek M.♦, Wierzchowski K.♦, Gadomska-Gajadhur A.♦, From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications,
Gels, ISSN: 2310-2861, DOI: 10.3390/gels9100788, Vol.9, No.788, pp.1-19, 2023 Abstract:
Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems. Keywords:
poly(glycerol itaconate), polylactide, electrospinning, tissue engineering, hydrogels Affiliations:
| Miętus M. | - | other affiliation | | Kolankowski K. | - | other affiliation | | Gołofit T. | - | other affiliation | | Denis P. | - | IPPT PAN | | Bandzerewicz A. | - | Warsaw University of Technology (PL) | | Spychalski M. | - | other affiliation | | Mąkosa-Szczygieł M. | - | other affiliation | | Pilarek M. | - | other affiliation | | Wierzchowski K. | - | other affiliation | | Gadomska-Gajadhur A. | - | Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL) |
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