| 1. |
Olusegun S.♦, Souza Guilhermina de O.♦, Sutuła S.♦, Osial M., Krajewski M.♦, Pękała M.♦, Sobczak K.♦, Felis E.♦, Krysiński P.♦, Methotrexate anti-cancer drug removal using Gd-doped Fe3O4: Adsorption mechanism, thermal desorption and reusability,
Groundwater for Sustainable Development, ISSN: 2352-801X, DOI: 10.1016/j.gsd.2024.101103, Vol.25, pp.1-9, 2024 Keywords:
Adsorption,Thermal desorption,Gd-doped Fe3O4,Methotrexate Affiliations:
| Olusegun S. | - | other affiliation | | Souza Guilhermina de O. | - | other affiliation | | Sutuła S. | - | other affiliation | | Osial M. | - | IPPT PAN | | Krajewski M. | - | other affiliation | | Pękała M. | - | other affiliation | | Sobczak K. | - | other affiliation | | Felis E. | - | other affiliation | | Krysiński P. | - | other affiliation |
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| 2. |
Olusegun S.♦, Osial M., Majkowska-Pilip A.♦, Żelechowska-Matysiak K.♦, Nieciecka D.♦, Krajewski M.♦, Pękała M.♦, Krysiński P.♦, Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application,
CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.03.102, pp.1-10, 2023Abstract:
Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells. Affiliations:
| Olusegun S. | - | other affiliation | | Osial M. | - | IPPT PAN | | Majkowska-Pilip A. | - | other affiliation | | Żelechowska-Matysiak K. | - | other affiliation | | Nieciecka D. | - | other affiliation | | Krajewski M. | - | other affiliation | | Pękała M. | - | other affiliation | | Krysiński P. | - | other affiliation |
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